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Arizona vs San Francisco NFL Odds & Result – Sep 27, 2026

NFL game: Arizona at San Francisco on Sunday, September 27, 2026 at 4:05 PM ET (NFL Week 3). Rotation numbers 481 (Arizona) and 482 (San Francisco).

Final score

Line score
RotTeam12341H2HFinal
481Arizona0671762430
482San Francisco710613171936

Betting lines

Betting lines
MarketOpenCloseResult
SpreadSan Francisco −8.5San Francisco −7.5Arizona covered
Total47.549▲ Over (66 pts)

The spread moved 1 point toward Arizona, from San Francisco −8.5 to San Francisco −7.5; the total rose from 47.5 to 49. Arizona lost by 6 and covered the closing spread of +7.5, beating the number by 1.5 points. The teams combined for 66 points, going over the closing total of 49 by 17 points.

Half lines

First and second half lines
MarketOpenCloseResult
1st half spreadSan Francisco −4.5 (−115)San Francisco −4.5San Francisco covered
1st half total23.5 (−115)24▼ Under
2nd half spreadSan Francisco −3.5 (−120)San Francisco −3 (−120)Arizona covered
2nd half total23.5 (−115)24 (−115)▲ Over

More

"Close" is the last line before the game. Spreads read from the favorite's side. Information only.